(−)-Guaiol, CAS 489-86-1

Formulation: A solid

Formal Name: (3S,5R,8S)-1,2,3,4,5,6,7,8-octahydro-α,α,3,8-tetramethyl-5-azulenemethanol

Purity: ≥95%

Formula Markup: C15H26O

Formula Weight: 222,4

Shelf life (days): 1460

CAS Number: 489-86-1

Notes: (−)-Guaiol is a sesquiterpene alcohol that has been found in several traditional Chinese medicinal plants and has antiproliferative, pro-autophagic, insect repellent, and insecticidal biological activities.{39874,39872,39873} It selectively inhibits proliferation of A549 and H1299 non-small cell lung carcinoma (NSCLC) cells over BEAS-2B normal lung cells (IC50s = 121.7, 211.5, and 297.1 μM, respectively).{39874} It also dose-dependently induces formation of DNA double-strand breaks (DSBs) and autophagy in A549 and H1299 cells and increases levels of microtubule-associated protein 1 light chain 3 isoform II (LC3-II). (−)-Guaiol (8 mg/kg three times per week) inhibits tumor growth in an NSCLC mouse xenograft model. It deters A. aegypti and A. quadrimaculatus mosquitoes from feeding on a synthetic blood substitute with a biting-deterrent index (BDI) of 0.82 when used at a concentration of 25 nmol per cm2.{39872} (−)-Guaiol is also lethal to fourth instar M. separata and third instar P. xylostella larvae (LD50s = 0.07 and 8.9 mg/larva, respectively).{39873}

• Artikelnummer: CAY23172-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23172-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK