1-(3-Chlorophenyl)biguanide (hydrochloride), CAS 2113-05-5

Formulation: A solid

Formal Name: N-(3-chlorophenyl)-imidodicarbonimidic diamide, monohydrochloride

Purity: ≥95%

Formula Markup: C8H10ClN5 • HCl

Formula Weight: 248,1

Shelf life (days): 1460

CAS Number: 2113-05-5

Notes: 1-(3-Chlorophenyl)biguanide (m-CPBG) is an agonist of the serotonin (5-HT) receptor subtype 5-HT3.{61629} It selectively binds 5-HT3 over 5-HT1A and 5-HT2 receptors (Kis = 0.002, 10, and 10 µM, respectively) but also binds to high and low affinity sites on the dopamine transporter (DAT; IC50s = 0.4 and 34.8 µM, respectively, in rat caudate putamen synaptosomal membranes).{61630,61631} m-CPBG induces depolarization of isolated rat vagus nerve and stimulates inositol phosphate formation in rat frontocingulate cortical slices (EC50s = 0.05 and 4.2 µM, respectively).{61629,61632} It induces bradycardia, an effect that can be reversed by the 5-HT3 receptor antagonist ondansetron, in anaesthetized cats (ED50 = 20.3 nmol/kg).{61629}

• Artikelnummer: CAY34726-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34726-25
• Green Labware: Nein
• Verpackungseinheit: 25 g
• Mengeneinheit: STK