(±)11(12)-EET, CAS 87173-81-7

Formulation: A solution in ethanol

Formal Name: rel-10-[(2R,3S)-3-(2Z)-2-octen-1-yl-2-oxiranyl]-5Z,8Z-decadienoic acid

Purity: ≥95%

Formula Markup: C20H32O3

Formula Weight: 320,5

Shelf life (days): 730

CAS Number: 87173-81-7

Notes: (±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid (Item No. 90010) by cytochrome P450 enzymes.{463,729,39722} A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24 while CYP2B2 produces a higher proportion of 11(S),12(R)-EET.{39722} 11(12)-EET has been shown, along with 8(9)-EET (Item No. 50351), to play a role in the recovery of depleted calcium pools in cultured smooth muscle cells.{5318} It also inhibits basolateral 18-pS potassium channels in the renal cortical collecting duct when used at a concentration of 100 nM.{39723} 11(12)-EET (50 µg/kg per day) increases adhesion of isolated peripheral blood leukocytes in a chamber coated with P-selectin and ICAM-1 but does not affect choroidal neovascularization size following laser photocoagulation.{39724} It also has anti-inflammatory, angiogenic, and cardioprotective properties.{39725}

• Artikelnummer: CAY50511-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 50511-50
• Green Labware: Nein
• Verpackungseinheit: 50 µg
• Mengeneinheit: STK