Formulation: A solid
Formal Name: (3α,5β)-3-hydroxy-12-oxo-cholan-24-oic acid
Purity: ≥98%
Formula Markup: C24H38O4
Formula Weight: 390,6
Shelf life (days): 1460
CAS Number: 5130-29-0
Notes: 12-keto Lithocholic acid is a metabolite of the secondary bile acid deoxycholic acid (DCA; Item Nos. 20756 / 18231).{46886,46887} Fecal levels of 12-keto lithocholic acid are elevated in rats fed a diet supplemented with cholic acid (Item No. 20250) or DCA compared with rats fed a control diet or a diet supplemented with cholesterol (Item No. 9003100), hyodeoxycholic acid (HDCA; Item No. 20294), or lithocholic acid (LCA; Item No. 20253).{46887} 12-keto Lithocholic acid activates the human pregnane X receptor (PXR; EC50 = 31.3 μM in a cell-based transactivation assay).{46888} 12-keto Lithocholic acid levels are increased in duodenal bile from patients with type 2 diabetes.{46889}