22(R)-hydroxy Cholesterol, CAS 17954-98-2

Formulation: A crystalline solid

Formal Name: cholest-5-ene-3β,22R-diol

Purity: ≥98%

Formula Markup: C27H46O2

Formula Weight: 402,7

Shelf life (days): 365

CAS Number: 17954-98-2

Notes: The liver X receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols.{8532} LXRs regulate the oxysterol-induced expression of cholesterol 7α-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. 22(R)-hydroxy Cholesterol is an endogenous agonist for LXRs that activates LXRα with an EC50 value of 325 nM.{9802} 22(R)-hydroxy Cholesterol, acting through LXR heterodimerized with the retinoid X receptor, induces the expression of the ABCA1 reverse cholesterol transporter.{9803} This activity increases the efflux of cholesterol from enterocytes and thus inhibits the overall absorption of cholesterol. 22(R)-hydroxy Cholesterol can be used as a substrate to monitor cholesterol transport or as an endogenous positive control for testing LXR agonists which have potential as therapeutic agents for the treatment of atherosclerosis.

• Artikelnummer: CAY89355-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 89355-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK