Formulation: A solution in ethanol
Formal Name: 4-oxo-5E,7Z,10Z,13Z,16Z,19Z-docosahexaenoic acid
Purity: ≥90%
Formula Markup: C22H30O3
Formula Weight: 342,5
Shelf life (days): 365
CAS Number: 845673-74-7
Notes: 4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA (Item No. 90310) with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 µM, however it increased proliferation of MCF-7 cells.{34687} 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and in dendritic cells with EC50 values of approximately 8-16 µM.{16872}