4A7C-301-Nurr1 Agonist

Formulation: A solid

Formal Name: N1-(4,6-bis(4-ethylpiperazin-1-yl)pyrimidin-2-yl)-N2-(7-chloroquinolin-4-yl)ethane-1,2-diamine

Purity: ≥98%

Formula Markup: C27H38ClN9

Formula Weight: 524,1

Shelf life (days): 730

Notes: 4A7C-301-Nurr1 agonist is an agonist of nuclear receptor-related 1 (Nurr1).{69457} It binds to the Nurr1 ligand-binding domain (LBD; IC50 = 48.22 nM) and increases transcriptional activity of Nurr1-LBD and full-length Nurr1 in reporter assays using SK-N-BE(2)C human neuroblastoma cells (EC50s = 6.53 and 50-70 µM, respectively). 4A7C-301-Nurr1 agonist (5 mg/kg per day) decreases dopaminergic cell death in the striatum and substantia nigra pars compacta, as well as reduces motor and olfactory deficits, without inducing dyskinesia-like behaviors in mouse models of Parkinson’s disease induced by the neurotoxin MPTP or by overexpression of α-synuclein.

• Artikelnummer: CAY39453-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39453-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK