4BP-TQS, CAS 360791-49-7

Formulation: A crystalline solid

Formal Name: 4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide

Purity: ≥98%

Formula Markup: C18H17BrN2O2S

Formula Weight: 405,3

Shelf life (days): 1460

CAS Number: 360791-49-7

Notes: 4BP-TQS is an allosteric agonist of α7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs).{47588} It activates human α7 subunit-containing nAChRs expressed in X. laevis oocytes more potently than acetylcholine (Item No. 23829; EC50s = 17 and 128 µM, respectively). It is selective for α7 subunit-containing nAChRs, having no activity for α1β1δε-, α3β4-, and α4β2 subunit-containing nAChRs at 100 µM.{47589} 4BP-TQS (10 µM) potentiates acetylcholine-induced activation of α7 subunit-containing nAChRs by greater than 540-fold in X. laevis oocytes.{47588} It activates wild-type α7 subunit-containing nAChRs and nAChRs containing the α7 subunit and W148F, but not M253L, mutations in X. laevis oocytes.

• Artikelnummer: CAY21881-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21881-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK