(±)5(6)-EET, CAS 87173-80-6

Formulation: A solution in ethanol

Formal Name: (±)5,6-epoxy-8Z,11Z,14Z-eicosatrienoic acid

Purity: ≥95% (mixture of free acid and lactone)

Formula Markup: C20H32O3

Formula Weight: 320,5

Shelf life (days): 365

CAS Number: 87173-80-6

Notes: 5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid (Item No. 90010) by cytochrome P450 enzymes.{463,729} In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS.{39654} In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5(6)-EET has been implicated in the mobilization of calcium and hormone secretion.{462,460} 5(6)-EET is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 (IC50 = 0.54 µM), and Cav3.3 and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 µM.{42110} In addition, it is a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 µM.{34481} (±)5(6)-EET is provided as a mixture of the free acid and lactone.

• Artikelnummer: CAY50211-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 50211-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK