5'-Deoxy-5'-methylthioadenosine-d3, CAS 174838-38-1

Formulation: A solid

Formal Name: 7-[5-S-(methyl-d3)-5-thio-β-D-ribofuranosyl]-7H-purin-6-amine

Purity: ≥99% deuterated forms (d1-d3)

Formula Markup: C11H12D3N5O3S

Formula Weight: 300,3

Shelf life (days): 1460

CAS Number: 174838-38-1

Notes: 5'-Deoxy-5'-methylthioadenosine-d3 (MTA-d3) is intended for use as an internal standard for the quantification of MTA (Item No. 15593) by GC- or LC-MS. MTA is an intermediate in the generation of adenine and methionine that is produced by the decarboxylation of S-adenosylmethionine.{25496} This nucleoside is a potent agonist of adenosine receptors (Kis = 0.15, 1.13, 13.9, and 0.68 μM for A1, A2A, A2B, and A3, respectively).{25499} At higher concentrations, MTA inhibits several enzymes, including protein carboxylmethyltransferase (Ki = 41 μM), S-adenosylhomocysteine hydrolase, SET methyltransferases, and spermidine and spermine synthases.{25497,25496,16624,25500}

• Artikelnummer: CAY27836-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 27836-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung