5α,6β-Dihydroxycholestanol, CAS 1253-84-5

Formulation: A crystalline solid

Formal Name: cholestane-3β,5α,6β-triol

Purity: ≥95%

Formula Markup: C27H48O3

Formula Weight: 420,7

Shelf life (days): 1460

CAS Number: 1253-84-5

Notes: 5α,6β-Dihydroxycholestanol is an oxysterol metabolite of cholesterol formed from conversion of cholesterol epoxides by 5,6-epoxysterol hydrolase.{41987,41988} It inhibits NMDA-mediated calcium influx in HEK293 cells expressing NR1/NR2B NMDA receptors in a concentration-dependent manner. It also binds to voltage-gated sodium (Nav) channels and decreases action potentials in hippocampal neurons in vitro when used at a concentration of 10 µM.{41988} It increases survival of spinal cord motoneurons, cortical neurons, and cerebellar granule neurons in vitro when used at concentrations ranging from 5 to 15 µM.{41989} 5α,6β-Dihydroxycholestanol is neuroprotective in a rat model of cerebral ischemia when administered at a dose of 12 mg/kg and increases latency to seizure onset and reduces severity of seizures induced by pentylenetetrazole (PTZ; Item No. 18682) in rats. 5α,6β-Dihydroxycholestanol has been used as a replacement for cholesterol in the study of cholesterol binding proteins.{41990}

• Artikelnummer: CAY25538-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25538-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK