5β-Dihydroprogesterone, CAS 128-23-4

Formulation: A solid

Formal Name: (5β)-pregnane-3,20-dione

Purity: ≥95%

Formula Markup: C21H32O2

Formula Weight: 316,5

Shelf life (days): 1460

CAS Number: 128-23-4

Notes: 5β-Dihydroprogesterone (5β-DHP) is a progesterone receptor agonist and metabolite of progesterone (Item No. 15876).{61565,61566} It is formed from progesterone by 5β-reductase.{61566} 5β-DHP inhibits spontaneous contractions in isolated rat uterus when used at a concentration of 10 µg/ml, an effect that can be blocked by the progesterone receptor antagonist RU486 (mifepristone; Item No. 10006317) but not the GABAA receptor antagonist picrotoxin (Item No. 20771).{61565} It is a negative modulator of homooligomeric ρ1 subunit-containing GABAA receptors, inhibiting GABA-induced currents in X. laevis oocytes expressing these receptors (IC50 = 5.02 µM).{61567} Plasma levels of 5β-DHP decrease at the onset of spontaneous human labor.{61568}

• Artikelnummer: CAY34644-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34644-1
• Green Labware: Nein
• Verpackungseinheit: 1 g
• Mengeneinheit: STK