6-hydroxy Bexarotene, CAS 368451-07-4

Formulation: A crystalline solid

Formal Name: 4-[1-(5,6,7,8-tetrahydro-6-hydroxy-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]-benzoic acid

Purity: ≥98%

Formula Markup: C24H28O3

Formula Weight: 364,5

Shelf life (days): 1460

CAS Number: 368451-07-4

Notes: 6-hydroxy Bexarotene is an oxidative metabolite of bexarotene (Item No. 11571), a high-affinity ligand for retinoid X receptors (RXRs).{35324} 6-hydroxy Bexarotene binds to RXRα, RXRβ, and RXRγ as well as retinoic acid receptor α (RARα; Kds = 3.46, 4.21, 4.83, and 8.17 μM, respectively). It selectively activates RXRα, RXRβ, and RXRγ over RARα, RARβ, and RARγ in vitro (EC50s = 398, 356, 420, 4,414, 2,121, and 2,043 nM, respectively).

• Artikelnummer: CAY22098-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22098-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK