6-hydroxy Melatonin, CAS 2208-41-5

Formulation: A crystalline solid

Formal Name: N-[2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl]-acetamide

Purity: ≥95%

Formula Markup: C13H16N2O3

Formula Weight: 248,3

Shelf life (days): 1460

CAS Number: 2208-41-5

Notes: 6-hydroxy Melatonin is an active metabolite of melatonin (Item No. 14427).{26017,34286,30338,60504,60505} It is formed from melatonin by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes.{60506} 6-hydroxy Melatonin is a melatonin 1A (MT1A), MT1B, and MT2 receptor agonist.{26017,34286} It inhibits dopamine release from isolated rabbit retina (IC50 = 0.0016 µM).{30338} 6-hydroxy Melatonin (10 and 100 µM) reduces increases in the levels of NF-κB, IL-6, and IL-8 and decreases in glutathione (GSH) levels in LPS- and peptidoglycan G-stimulated human umbilical vein endothelial cells (HUVECs) in an in vitro model of sepsis.{60504} It reduces iron-induced lipid oxidation in rat hippocampal homogenate when administered at a dose of 10 mg/kg.{60505}

• Artikelnummer: CAY21857-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21857-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK