7-Chlorokynurenic Acid, CAS 18000-24-3

Formulation: A crystalline solid

Formal Name: 7-chloro-4-hydroxy-2-quinolinecarboxylic acid

Purity: ≥95%

Formula Markup: C10H6ClNO3

Formula Weight: 223,6

Shelf life (days): 1460

CAS Number: 18000-24-3

Notes: 7-Chlorokynurenic acid is an NMDA receptor antagonist.{62046} It selectively binds to the NMDA receptor glycine-binding site (IC50 = 0.56 µM) over the NMDA-, quisqualate-, and kainate-binding sites (IC50s = 169, 153, and >1,000 µM, respectively). Intra-dorsal hippocampal administration of 7-chlorokynurenic acid (3.2 µg per side) increases the number of errors in a three-panel runway test of working memory, an effect that can be blocked by the NMDA glycine-site co-agonist D-serine (Item No. 31197).{62047} It also induces antidepressant-like activity in the forced swim test, novelty-suppressed feeding test, and a foot shock-based learned helplessness test in mice when administered at doses of 0.1 and 1 mg/kg.{62048}

• Artikelnummer: CAY33408-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33408-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK