7-hydroxy DPAT (hydrobromide), CAS 76135-30-3

Formulation: A crystalline solid

Formal Name: 7-(dipropylamino)-5,6,7,8-tetrahydro-2-naphthalenol, monohydrobromide

Purity: ≥95%

Formula Markup: C16H25NO • HBr

Formula Weight: 328,3

Shelf life (days): 1460

CAS Number: 76135-30-3

Notes: 7-hydroxy DPAT is a dopamine D3 receptor agonist.{52357} It selectively binds to the dopamine D3 over the D2, D1, and D4 receptors (Kis = 0.78, 61, 650, and 5,300 nM, respectively, in radioligand binding assays). 7-hydroxy DPAT increases calcium mobilization in HEK293 cells expressing the D3 receptor with an EC50 value of 13.5 nM in a FLIPR assay.{52358} It decreases the release of striatal dopamine and its metabolite 3,4-dihydroxyphenylacetic acid (DOPAC; Item No. 24912) in rats when administered intraperitoneally at a dose of 0.25 mg/kg.{52359} 7-hydroxy DPAT (2 µg/µl for eight weeks, i.c.v.) reduces the loss of ipsilateral substantia nigra pars compacta (SNC) dopaminergic neurons in a rat model of Parkinson's disease induced by 6-OHDA (Item No. 25330).{52360} It also decreases amphetamine-induced ipsilateral rotations and increases the number of steps reached with the contralateral paw in the staircase test in the same model.

• Artikelnummer: CAY29516-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29516-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK