(±)9-HEPE, CAS 286390-03-2

Formulation: A solution in ethanol

Formal Name: (±)-9-hydroxy-5Z,7E,11Z,14Z,17Z-eicosapentaenoic acid

Purity: ≥98%

Formula Markup: C20H30O3

Formula Weight: 318,5

Shelf life (days): 365

CAS Number: 286390-03-2

Notes: (±)9-HEPE is a racemic mixture of the monohydroxy fatty acids 9(R)-HEPE and 9(S)-HEPE (Item No. 32410). It is produced by non-enzymatic oxidation of eicosapentaenoic acid (EPA; Item Nos. 90110 / 21908 / 90110.1).{29249} (±)9-HEPE (128 µM) induces peroxisome proliferator-activated receptor α (PPARα), PPARγ, and PPARδ transactivation in NIH3T3 cells expressing the mouse receptors.{66194} It reduces increases in the expression of the genes encoding inducible nitric oxide synthase (iNOS), TNF-α, IL-1β, and IL-6 in isolated mouse peritoneal macrophages induced by palmitate, as well as inhibits palmitate-induced migration of isolated mouse peritoneal macrophages, when used at a concentration of 1 µM.{66195} (±)9-HEPE decreases hepatic triglyceride levels and plasma LDL-cholesterol and total cholesterol levels in a mouse model of high-fat diet-induced hepatic steatosis when administered in combination with (±)5-HEPE (Item No. 32200) and (±)17,18-EEQ ((±)17(18)-EpETE; Item No. 50861).

• Artikelnummer: CAY32400-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 32400-100
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK