A-1120, CAS 1152782-19-8

Formulation: A crystalline solid

Formal Name: 2-[[[4-[2-(trifluoromethyl)phenyl]-1-piperidinyl]carbonyl]amino]-benzoic acid

Purity: ≥95%

Formula Markup: C20H19F3N2O3

Formula Weight: 392,4

Shelf life (days): 1460

CAS Number: 1152782-19-8

Notes: A-1120 is a non-retinoid retinol binding protein 4 (RBP4) antagonist (Ki = 8.3 nM for disruption of RBP4 binding to transthyretin).{58011} It is selective for RBP4 over cellular retinol binding protein 1 (CRBP1; IC50s = 0.09 and >30 µM, respectively, in radioligand binding assays), as well as a panel of G protein-coupled receptors, kinases, and enzymes. A-1120 (30 mg/kg) reduces serum levels of RBP4 and retinol in mice. It also inhibits retinal bisretinoid accumulation in the Abca4-/- mouse model of enhanced retinal lipofuscinogenesis-induced macular degeneration.{58012}

• Artikelnummer: CAY30921-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30921-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK