A-740003, CAS 861393-28-4

Formulation: A crystalline solid

Formal Name: N-[1-[[(cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxy-benzeneacetamide

Purity: ≥98%

Formula Markup: C26H30N6O3

Formula Weight: 474,6

Shelf life (days): 1460

CAS Number: 861393-28-4

Notes: A-740003 is a competitive antagonist of the ATP-gated ionotropic P2X7 receptor (IC50s = 40 and 18 nM for human and rat receptors, respectively).{33388} It shows weak or no activity at other P2 receptors and other receptors and ion channels. A-740003 blocks agonist-induced IL-1β release and pore formation in differentiated THP-1 cells (IC50s = 156 and 92 nM, respectively).{33388} It is effective in vivo when administered intraperitoneally, reducing pain in several animal models.{33388} A-740003 is used in cell and animal studies to elucidate P2X7 roles and signaling pathways.{22913,33386,33387}

• Artikelnummer: CAY21256-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21256-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK