A-839977, CAS 870061-27-1

Formulation: A crystalline solid

Formal Name: 1-(2,3-dichlorophenyl)-N-[[2-(2-pyridinyloxy)phenyl]methyl]-1H-tetrazol-5-amine

Purity: ≥98%

Formula Markup: C19H14Cl2N6O

Formula Weight: 413,3

Shelf life (days): 1460

CAS Number: 870061-27-1

Notes: A-389977 is an antagonist of the purinergic P2X7 receptor.{57152} It inhibits BzATP-evoked intracellular calcium influx in 1321N1 cells expressing human, rat, and mouse receptors (IC50s = 20, 42, and 150 nM, respectively). A-839977 inhibits BzATP-induced YO-PRO dye uptake, a marker of membrane pore formation, and IL-1β release from THP-1 cells (IC50s = 6.6 and 37 nM, respectively). In vivo, A-389977 (30, 100, and 300 µmol/kg, i.p.) reduces thermal hyperalgesia in rats. A-389977 (40 mg/kg) reduces thermal and mechanical hyperalgesia in a rat MRMT-1 mammary carcinoma model of cancer-induced bone pain.{57151}

• Artikelnummer: CAY30934-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30934-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK