A-841720, CAS 869802-58-4

Formulation: A crystalline solid

Formal Name: 9-(dimethylamino)-3-(hexahydro-1H-azepin-1-yl)-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one

Purity: ≥98%

Formula Markup: C17H21N5OS

Formula Weight: 343,5

Shelf life (days): 1460

CAS Number: 869802-58-4

Notes: A-841720 is a noncompetitive antagonist of the group 1 metabotropic glutamate receptor mGluR1 with an IC50 value of 10.7 nM for inhibition of L-glutamate-induced calcium release in 1321 N1 cells.{40808} It is selective for mGluR1 over mGluR5 (IC50 = 343 nM) as well as mGluR2, mGluR4, and mGluR7, where it does not inhibit agonist-induced calcium release in HEK293 cells. It is also selective for mGluR1 over a panel of other G-coupled protein receptors as well as ligand- and voltage-gated ion channels at a concentration of 10 µM. A-841720 dose-dependently inhibits complete Freund's adjuvant-induced inflammatory pain (ED50 = 23 µmol/kg) and sciatic nerve injury-induced mechanical allodynia (ED50 = 28 µmol/kg) in rats. It also enhances cocaine seeking in mice after a prolonged abstinence following a single conditioning session when administered at a dose of 10 mg/kg per day.{40809}

• Artikelnummer: CAY21807-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21807-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK