Formulation: A crystalline solid
Formal Name: 4-[5-(4-chlorophenyl)-2-methyl-3-(1-oxopropyl)-1H-pyrrol-1-yl]-benzenesulfonamide
Purity: ≥98%
Formula Markup: C20H19ClN2O3S
Formula Weight: 402,9
Shelf life (days): 1460
CAS Number: 1000279-69-5
Notes: A-867744 is a positive allosteric modulator of α7 nicotinic acetylcholine receptors (nAChRs).{52986} It is selective for α7 nAChRs over α3β2- or α4β2 subunit-containing nAChRs (IC50s = 0.023, 19.5 and 6.4 µM, respectively) and the serotonin (5-HT) receptor subtype 5-HT3A (Ki = >30 µM). A-867744 potentiates ACh-induced currents in Xenopus oocytes expressing human α7 nAChRs (EC50 = ~1 µM). In vivo, A-867744 (0.1-10 μmol/kg, i.p.) improves sensory gating deficits in a paired auditory stimulus paradigm in mice.{52987}