A-971432, CAS 1240308-45-5

Formulation: A crystalline solid

Formal Name: 1-[[4-[(3,4-dichlorophenyl)methoxy]phenyl]methyl]-3-azetidinecarboxylic acid

Purity: ≥98%

Formula Markup: C18H17Cl2NO3

Formula Weight: 366,2

Shelf life (days): 1460

CAS Number: 1240308-45-5

Notes: A-971432 is a sphingosine-1-phosphate receptor 5 (S1P5) agonist that is selective for S1P5 over S1P1 and S1P3 (IC50s = 0.006, 0.362, and >10 µM, respectively).{42320} It inhibits forskolin-induced cAMP production in CHO cells expressing S1P5 (EC50 = 4.1 nM). A-971432 (1 µM) increases electrical resistance of hCMEC/D3 cells in an in vitro blood-brain barrier model, indicating enhanced barrier integrity, and attenuates blood-brain barrier leakage in an R6/2 transgenic mouse model of Huntington's disease when administered at a dose of 0.1 mg/kg.{42320,42321} A-971432 (0.1 mg/kg per day, i.p.) decreases the number of errors made in a horizontal ladder task and increases latency to fall in the rotarod test in R6/2 mice. It also increases spontaneous alternation in the t-maze in aged mice when administered at a dose of 0.1 mg/kg.{42320}

• Artikelnummer: CAY25326-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25326-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK