α-Conotoxin ImI (trifluoroacetate salt)

Formulation: A solid

Formal Name: glycyl-L-cysteinyl-L-cysteinyl-L-seryl-L-α-aspartyl-L-prolyl-L-arginyl-L-cysteinyl-L-alanyl-L-tryptophyl-L-arginyl-L-cysteinamide, cyclic (2→8),(3→12)-bis(disulfide), trifluoroacetate salt

Purity: ≥98%

Formula Markup: C52H78N20O15S4 • XCF3COOH

Formula Weight: 1351,6

Shelf life (days): 1460

Notes: α-Conotoxin ImI is a conotoxin that has been found in C. imperialis and has receptor antagonist and anticancer activities.{62392} It is a peptide antagonist of homomeric α7 nicotinic acetylcholine receptors (nAChRs; IC50 = 220 nM). α-Conotoxin ImI is selective for α7 nAChRs over α2β2, α3β2, α4β2, α2β4, α3β4, α4β4, and α1β1γδ subunit-containing nAChRs at 5 µM but does inhibit homomeric α9 nAChRs (IC50 = 1,800 nM). Administration of paclitaxel (Item No. 10461) in micelles containing α-conotoxin ImI decreases tumor growth in an MCF-7 mouse xenograft model.{62393} Intracerebroventricular, but not intraperitoneal, administration of α-conotoxin ImI (20 nmol/animal) induces seizures in rats.{62394}

• Artikelnummer: CAY34022-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34022-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK