(−)-(α)-Kainic Acid (hydrate), CAS 58002-62-3

Formulation: A crystalline solid

Formal Name: 2S-carboxy-4S-(1-methylethenyl)-3S-pyrrolidineacetic acid, monohydrate

Purity: ≥98%

Formula Markup: C10H15NO4 • H2O

Formula Weight: 231,2

Shelf life (days): 1460

CAS Number: 58002-62-3

Notes: (−)-(α)-Kainic acid is a cyclic analog of L-glutamate originally isolated from D. simplex that has neuroexcitatory activities.{55282} It binds to the homomeric kainate receptors GluK1, GluK2, GluK3, GluK4, and GluK5 (Kis = 75.9, 12.7, 32.8, 4.7, and 15 nM, respectively).{55283} (−)-(α)-Kainic acid (5 mM) induces calcium influx and membrane depolarization, as well as glutamate release, in rat brain synaptosomes.{55284} It induces chromatin condensation and nuclear membrane fragmentation, markers of apoptosis, in primary neonatal cerebellar granule neurons when used at a concentration of 100 µM.{55285} Intracerebroventricular administration of (−)-(α)-kainic acid induces convulsive behavior in rats (ED50 = 0.51 nmol/animal) and induces seizures in mice with a 50% convulsive dose (CD50) value of 0.39 nmol/animal.{41914} It has been commonly used to induce seizures in rodents.{55286,23784}

• Artikelnummer: CAY78050-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 78050-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK