α-Mangostin, CAS 6147-11-1

Formulation: A crystalline solid

Formal Name: 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one

Purity: ≥95%

Formula Markup: C24H26O6

Formula Weight: 410,5

Shelf life (days): 1460

CAS Number: 6147-11-1

Notes: α-Mangostin is a xanthone that has been found in G. mangostana and has diverse biological activities.{39821,39824,56091,56092,56093} It inhibits fatty acid synthase and HIV-1 protease (IC50s = 5.54 and 5.12 μM, respectively).{39824,56091} α-Mangostin is active against methicillin-sensitive and -resistant S. aureus strains (MICs = 1.57-12.5 μg/ml).{39821} It inhibits nitric oxide and prostaglandin E2 (PGE2; Item No. 14010) production in LPS-stimulated RAW 264.7 cells (IC50s = 12.4 and 11.08 μM, respectively).{56092} α-Mangostin is an agonist of stimulator of interferon genes (STING) that binds to the C-terminal domain of STING (H232 variant) with a Kd value of 137 μM and induces expression of an IFN-β-luciferase reporter in HEK293T cells transfected with human STING (H232 variant) to a greater extent than cells expressing murine STING or human STING (R232 variant) when used at a concentration of 25 μM.{56103} α-Mangostin (20 mg/kg) prevents carrageenan-induced paw edema in mice. It decreases the viability of LNCaP, 22Rv1, DU145, and PC3 prostate cancer cells in vitro (IC50s = 5.9, 6.9, 22.5, and 12.7 μM, respectively) and reduces tumor growth in a 22Rv1 mouse xenograft model when administered at a dose of 100 mg/kg.{56093}

• Artikelnummer: CAY29108-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29108-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK