AB-MECA, CAS 152918-26-8

Formulation: A crystalline solid

Formal Name: 1-[6-[[(4-aminophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl-β-D-ribofuranuronamide

Purity: ≥98%

Formula Markup: C18H21N7O4

Formula Weight: 399,4

Shelf life (days): 1460

CAS Number: 152918-26-8

Notes: AB-MECA is an adenosine A3 receptor agonist (Ki = 430.5 nM for the human receptor expressed in CHO cells).{45426} It inhibits LPS-induced TNF-α production in primary cultured human lung macrophages (pD2 = 6.9).{45427} AB-MECA increases contraction of isolated guinea pig trachea ex vivo when used at a concentration of 0.1 μM and increases bronchoconstriction in vivo when administered at a dose of 3 μg/kg in a guinea pig model of ovalbumin-sensitized asthma.{45428} A radiolabeled form of AB-MECA has been used for radioligand binding assays and binds to rat adenosine A1 and A3 receptors (Kds = 3.42 and 1.48 nM in COS-7 and CHO cells, respectively) and canine adenosine A2a receptors (Kd = 25.1 nM in COS-7 cells).{45429}

• Artikelnummer: CAY28415-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28415-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK