Abarelix (acetate), CAS 785804-17-3

Formulation: A crystalline solid

Formal Name: N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N-methyl-L-tyrosyl-D-asparaginyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl-D-alaninamide, acetate salt

Purity: ≥95%

Formula Markup: C72H95ClN14O14 • XC2H4O2

Formula Weight: 1416,1

Shelf life (days): 1460

CAS Number: 785804-17-3

Notes: Abarelix is a synthetic third generation gonadotropin-releasing hormone receptor (GnRHR) antagonist (IC50 = 3.5 nM in HEK293 cells expressing the human receptor).{48583,39553} In vivo, abarelix (200 μg/kg) decreases plasma luteinizing hormone (LH) levels six hours post-treatment in castrated rats, with levels returning to baseline within 24 hours.{48584} Abarelix (2 mg/kg) also transiently decreases plasma testosterone levels in intact rats, with levels returning to baseline within seven days post-treatment. Formulations containing abarelix have previously been used in the treatment of advanced prostate cancer.

• Artikelnummer: CAY28746-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28746-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK