ABT-724 (hydrochloride), CAS 587870-77-7

Formulation: A solid

Formal Name: 2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole, trihydrochloride

Purity: ≥98%

Formula Markup: C17H19N5 • 3HCl

Formula Weight: 402,8

Shelf life (days): 1460

CAS Number: 587870-77-7

Notes: ABT-724 is a dopamine D4 receptor agonist with an EC50 value of 12.4 nM in a FLIPR calcium flux assay using HEK293 cells expressing the human D4.4 receptor and Gαqo5.{45687} It is selective for dopamine D4 over D2 receptors at 10 μM. ABT-724 (0.03 μmol/kg) induces penile erections in 77% of male rats. It decreases mounting frequency and ejaculation latency and increases ejaculation frequency and copulatory efficacy in male rats when administered at a dose of 0.04 mg/kg.{45688} ABT-724 (0.16 and 0.64 mg/kg) decreases hyperactivity and exploratory behavior in the open field test in an adolescent spontaneously hypertensive rat (SHR) model of attention-deficit hyperactivity disorder (ADHD).{45689}

• Artikelnummer: CAY29506-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29506-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK