Acebutolol-d7, CAS 2701782-36-5

Formulation: A solid

Formal Name: N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl-d7)amino]propoxy]phenyl]-butanamide

Purity: ≥99% deuterated forms (d1-d7)

Formula Markup: C18H21D7N2O4

Formula Weight: 343,5

Shelf life (days): 1460

CAS Number: 2701782-36-5

Notes: Acebutolol-d7 is intended for use as an internal standard for the quantification of acebutolol (Item No. 23393) by GC- or LC-MS. Acebutolol is an antagonist of β1-adrenergic receptors (β1-ARs; Ki = 125 nM).{26306} It is selective for β1- over β2-ARs (Ki = 7,070 nM). In vivo, acebutolol decreases isoprenaline-induced tachycardia and diastolic hypotension in cats (ED50 = 0.09 mg/kg for both).{39375} Acebutolol (12.5, 25, and 50 mg/kg) inhibits ouabain-induced arrhythmias in rabbits, as well as protects against chloroform-induced ventricular fibrillation in mice (ED50 = 0.067 mg/kg).{39376} Formulations containing acebutolol have been used in the treatment of angina and irregular heartbeat.

• Artikelnummer: CAY35557-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35557-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung