ACTH (1-10) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

Formulation: A solid

Formal Name: L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophyl-glycine, trifluoroacetate salt

Purity: ≥95%

Formula Markup: C59H78N16O16S • XCF3COOH

Formula Weight: 1299,4

Shelf life (days): 1460

Notes: Adrenocorticotropic hormone (ACTH) (1-10) is an N-terminal peptide fragment of ACTH, a peptide hormone produced by the anterior pituitary gland that is involved in the biological stress response.{49033,45140} The amino acid sequence of ACTH (1-10) is common to ACTH and α-melanocyte stimulating hormone.{45139} ACTH (1-10) is an agonist of melanocortin receptor 3 (MC3R) and MC4R (EC50s = 2.6 and 200 nM, respectively, for the recombinant human receptors) and increases adenylate cyclase activity in HEK293 cells expressing human recombinant MC1R (EC50 = 25 nM).{45139,49034} It inhibits extinction of the conditioned avoidance response rats in shuttle-box and pole-jumping tests when administered at doses of 10 and greater than 20 μg, respectively.{49033,49035} Intracerebroventricular injection of ACTH (1-10) reduces the incidence and severity of cold-restraint stress-induced gastric lesions in rats.{49036}

• Artikelnummer: CAY27105-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 27105-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK