ACTH (1-17) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

Formulation: A solid

Formal Name: α1-17-corticotropin, trifluoroacetate salt

Purity: ≥98%

Formula Markup: C95H145N29O23S • XCF3COOH

Formula Weight: 2093,4

Shelf life (days): 1460

Notes: ACTH (1-17) is a peptide fragment of adrenocorticotropic hormone (ACTH; Item No. 24257), a peptide hormone found in the brain that is involved in the biological stress response.{45140} It binds to melanocortin receptors (MCRs; Kis = 0.23, 14, 419, and 4,240 nM for MC1R, MC3R, MC4R, and MC5R, respectively).{48427} It is an agonist at MC1R, increasing adenylate cyclase activity with an EC50 value of 3.02 nM in HEK293 cells expressing MC1R.{49034} ACTH (1-17) (160 µg/kg, i.v.) increases mean arterial blood pressure (MAP) following bleeding-induced hypotension in a rat model of hemorrhagic shock 15-30 minutes after administration.{48428} It induces melanogenesis in a biphasic manner (EC50s = 0.0001 and 0.08 nM) and differentiation of melanocytes when used at concentrations ranging from 0.01 to 1,000 nM.{49034,48426}

• Artikelnummer: CAY27429-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 27429-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK