Adomeglivant, CAS 1488363-78-5

Formulation: A solid

Formal Name: N-[4-[(1S)-1-[[4′-(1,1-dimethylethyl)-2,6-dimethyl[1,1′-biphenyl]-4-yl]oxy]-4,4,4-trifluorobutyl]benzoyl]-β-alanine

Purity: ≥98%

Formula Markup: C32H36F3NO4

Formula Weight: 555,6

Shelf life (days): 1460

CAS Number: 1488363-78-5

Notes: Adomeglivant is an allosteric antagonist of the glucagon receptor.{47796,47797} It inhibits glucagon-induced increases in cAMP levels in HEK293 cells expressing the rat glucagon or GLP-1 receptors (IC50s = 1.8 and 1.2 µM, respectively) but has no effect on cAMP levels when used alone.{47797} Adomeglivant also inhibits increases in cAMP levels induced by GLP-1 or exendin-4 (48-86) amide (Item No. 11096) in HEK293 cells expressing the GLP-1 receptor (IC50s = 7 and 12 µM, respectively). It decreases glucose-stimulated insulin secretion when used at a concentration of 1 µM in combination with the GLP-1 receptor antagonist exendin (9-39) in isolated human islets but not glucose-stimulated glucagon secretion when used alone or in combination with exendin (9-39) in isolated mouse islets.{47798}

• Artikelnummer: CAY29668-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29668-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK