AF-DX 384, CAS 118290-26-9

Formulation: A solid

Formal Name: N-[2-[2-[(dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide

Purity: ≥95%

Formula Markup: C27H38N6O2

Formula Weight: 478,6

Shelf life (days): 1460

CAS Number: 118290-26-9

Notes: AF-DX 384 is an antagonist of M2 and M4 muscarinic acetylcholine receptors (Kis = 6.03 and 10 nM, respectively).{42379} It is selective for M2 and M4 over M1, M3, and M5 receptors (Kis = 30.9, 66.07, and 537.03 nM, respectively). AF-DX 384 increases acetylcholine release in the hippocampus and cortex of young and aged rats in vivo when infused locally at a concentration of 1 µM and in the cortex when administered intraperitoneally at a dose of 5 mg/kg.{42380} It reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine (Item No. 14108).

• Artikelnummer: CAY25638-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25638-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK