AF38469, CAS 1531634-31-7

Formulation: A solid

Formal Name: 2-[[(6-methyl-2-pyridinyl)amino]carbonyl]-5-(trifluoromethyl)-benzoic acid

Purity: ≥98%

Formula Markup: C15H11F3N2O3

Formula Weight: 324,3

Shelf life (days): 1460

CAS Number: 1531634-31-7

Notes: AF38469 is an inhibitor of sortilin, also known as the neurotensin-3 receptor (NTS3; IC50 = 330 nM).{66001} It is selective for sortilin over neurotensin-1 (NTS1), δ-opioid, angiotensin II type 1 (AT1), endothelin A (ETA), and ETB receptors, GPR40, PPARδ, and matrix metalloproteinase-12 (MMP-12), and the prostaglandin E2 (PGE2) receptor subtype EP1. AF38469 (400 nM) inhibits the epithelial-to-mesenchymal transition (EMT) in, and reduces migration and invasion of, U87 and A172 glioblastoma cells.{66002} It also reduces tumor growth in a glioblastoma multiforme mouse xenograft model when administered at a dose of 0.01 g/kg per day.

• Artikelnummer: CAY35530-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35530-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe