Afobazole (hydrochloride), CAS 173352-39-1

Formulation: A solid

Formal Name: 6-ethoxy-2-[[2-(4-morpholinyl)ethyl]thio]-1H-benzimidazole, monohydrochloride

Purity: ≥98%

Formula Markup: C15H21N3O2S • HCl

Formula Weight: 343,9

Shelf life (days): 1460

CAS Number: 173352-39-1

Notes: Afobazole is a multi-targeted anxiolytic drug with neuroprotective activities.{46420,46421} It binds to the sigma-1, melatonin MT1, and MT3 receptors, as well as monoamine oxidase A (MAO-A; Kis = 5.9, 160, 0.97, and 3.6 µM, respectively, in a radioligand binding assay).{46420} Afobazole (5 mg/kg) decreases the latency to enter, as well as increases the number of entries into and percentage of time spent in, the open arms of the elevated plus maze, indicating anxiolytic-like activity in passive stress-coping BALB/c, but not active stress-coping C57BL/6, mice.{46422} It decreases stroke volume and neuronal and oligodendroglial cell death in the brain in a rat model of ischemia induced by middle cerebral artery occlusion (MCAO) when administered at doses of 0.3 and 3 mg/kg.{46421}

• Artikelnummer: CAY22923-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22923-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK