Agmatine (sulfate), CAS 2482-00-0

Formulation: A crystalline solid

Formal Name: N-(4-aminobutyl)-guanidine, monosulfate

Purity: ≥98%

Formula Markup: C5H14N4 • H2SO4

Formula Weight: 228,3

Shelf life (days): 1460

CAS Number: 2482-00-0

Notes: Agmatine is a metabolite formed during polyamine biosynthesis with diverse biological activities.{37373} Agmatine is released from and taken up by synaptosomes, demonstrating neurotransmitter-like activity. It binds to human adrenergic receptors (ARs) and imidazoline (I) receptors (Kis = 46.98, 164.4, 26.3, and 74.4 μM for α2A-, α2B-, and α2c-ARs and I2b, respectively).{37374} Agmatine acts as an antagonist of the NMDA receptor (NMDAR) in a voltage- and concentration-dependent manner in primary rat hippocampal neurons and antagonizes nicotinic acetylcholine receptors (nAChRs) in intact chick retina at 1 mM.{37375},{37376} It is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 in mouse N1E-115 neuroblastoma cells (IC50 = 141 μM) and blocks ATP-sensitive potassium channels (KATP) in a concentration-dependent manner in mouse islets of Langerhans β-cells.{37377},{37378} Agmatine competitively inhibits neuronal, macrophage, endothelial, and inducible nitric oxide synthase (NOS; Kis = 660, 220, 7,500, and 260 μM, respectively) and irreversibly inactivates neuronal NOS in the presence of calmodulin (Ki = 29 μM).{37379} In vivo, agmatine (10 mg/kg) lowers the ED50 value by 5.2- and 4.7-fold for morphine (Item No. ISO60147) and [D-Pen2,D-Pen5]enkephalin (DPDPE), respectively, in mice in a tail flick assay.{37380} It increases the nephron filtration rate when microperfused into the urinary space of rats, an effect that is reversed by the non-selective NOS inhibitor L-NG-monomethyl arginine (L-NMMA; Item Nos. 80200, 10005031).{37381}

• Artikelnummer: CAY23513-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23513-10
• Green Labware: Nein
• Verpackungseinheit: 10 g
• Mengeneinheit: STK