Ajmaline, CAS 4360-12-7

Formulation: A crystalline solid

Formal Name: (17R,21α)-ajmalan-17,21-diol

Purity: ≥95%

Formula Markup: C20H26N2O2

Formula Weight: 326,4

Shelf life (days): 1460

CAS Number: 4360-12-7

Notes: Ajmaline is an alkaloid that has been found in R. serpentina and has ion channel inhibitory and antiarrhythmic activities.{46769,46770,46771,46772,46773} It inhibits the human-ether-a-go-go (hERG) potassium channel, also known as Kv11.1, and the voltage-gated potassium channel subtypes Kv1.5 and Kv4.3 with IC50 values of 42.3, 293, and 186 µM, respectively, in Xenopus oocytes expressing the channels.{46770,46771} Ajmaline (1 µg/ml) increases the action potential duration in isolated dog atrium and ventricle.{46772} It increases the functional refractory duration in the atrium, ventricle, and atrioventricular conduction system in anesthetized dogs when administered intravenously at a dose of 1 mg/kg.{46772} Ajmaline (2 mg/kg, i.v.) reduces the number of premature ventricular complexes and decreases the duration of ventricular tachycardia and ventricular fibrillation in coronary artery-ligated anesthetized rats.{46773}

• Artikelnummer: CAY29962-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29962-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK