(Ala1)-PAR4 (1-6) amide (mouse) (trifluoroacetate salt)

Formulation: A lyophilized powder

Formal Name: L-alanyl-L-tyrosyl-L-prolylglycyl-L-lysyl-L-phenylalaninamide, trifluoroacetate salt

Purity: ≥95%

Formula Markup: C34H48N8O7 • XCF3COOH

Formula Weight: 680,8

Shelf life (days): 1460

Notes: (Ala1)-PAR4 (1-6) amide (mouse) is a peptide agonist of proteinase-activated receptor 4 (PAR4) that induces aggregation of rat and human platelets in vitro (EC50s = 15 and 60 μM, respectively).{36394,36395} It reduces expression of glycoprotein (GP) Ib, and increases expression of GPIIb/IIIa on the surface of human platelets.{36395} (Ala1)-PAR4 (1-6) amide (mouse) induces relaxation of isolated rat aortic rings and contraction of rat gastric longitudinal muscle strips (EC50s = 11 and 110 μM, respectively) as well as inhibits calcium mobilization evoked by capsaicin (Item No. 92350) in rat sensory neurons.{36396,36397} In vivo, (Ala1)-PAR4 (1-6) amide (mouse) (1-100 µg) increases latency to paw withdrawal and the nociceptive threshold in response to thermal and mechanical stimuli.{36397} (Ala1)-PAR4 (1-6) amide (mouse) (200 µg) also increases paw thickness in a rat paw edema assay.

• Artikelnummer: CAY24258-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24258-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK