Alaproclate (hydrochloride), CAS 60719-83-7

Formulation: A crystalline solid

Formal Name: alanine, 2-(4-chlorophenyl)-1,1-dimethylethyl ester, monohydrochloride

Purity: ≥95%

Formula Markup: C13H18ClNO2 • HCl

Formula Weight: 292,2

Shelf life (days): 1460

CAS Number: 60719-83-7

Notes: Alaproclate is a selective serotonin reuptake inhibitor (SSRI).{27770,45384} It inhibits depletion of serotonin (5-HT) induced by 4-methyl-α-ethyl-m-tyramine in rat cerebral cortex, hippocampus, hypothalamus, and striatum (EC50s = 18, 4, 8, and 12 mg/kg, respectively).{27770} Alaproclate inhibits NMDA-evoked currents and depolarization-induced voltage-dependent potassium currents in rat hippocampal neurons (IC50s = 1.1 and 6.9 μM, respectively) and does not inhibit GABA-evoked currents when used at concentrations up to 100 μM.{45384} It increases sirtuin 1 (SIRT1) levels in N2a murine neuroblastoma cells expressing apolipoprotein E4 (ApoE4; IC50 = 2.3 μM) and in the hippocampus in the FXFAD-ApoE4 transgenic mouse model of Alzheimer's disease when administered at a dose of 20 mg/kg twice daily.{35772} Alaproclate (40 mg/kg) decreases immobility time in the forced swim test in rats, indicating antidepressant-like activity.{45385}

• Artikelnummer: CAY27770-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 27770-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK