Alarelin (acetate), CAS 79561-22-1

Formulation: A crystalline solid

Formal Name: 6-D-alanine-9-(N-ethyl-L-prolinamide)-1-9-luteinizing hormone-releasing factor (swine), diacetate

Purity: ≥98%

Formula Markup: C56H78N16O12 • 2C2H4O2

Formula Weight: 1287,4

Shelf life (days): 1460

CAS Number: 79561-22-1

Notes: Alarelin is a peptide agonist of gonadotropin-releasing hormone (GnRH).{36464} It binds to the GnRH receptor (GnRHR) with a Kd value of 0.2 nM. Alarelin (6 ng, i.c.v.) decreases the expression of GnRH in the preoptic area and GnRHR in the posterior mediobasal hypothalamus (pMBH) of ovariectomized estradiol-treated rats, indicating an ultrashort negative feedback loop on GnRH and GnRHR gene expression.{57077} It induces desensitization in the pituitary and decreases serum estradiol levels and ovarian and uterine weight in neonatal and adult female rats.{57078} Alarelin reduces tumor growth in an HEC-1-B human endometrial carcinoma mouse xenograft model when administered at doses of 20, 40, and 80 µg/kg.{57079}

• Artikelnummer: CAY30993-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30993-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK