Alloisolithocholic Acid, CAS 2276-93-9

Formulation: A solid

Formal Name: (5α)-3β-hydroxy-cholan-24-oic acid

Purity: ≥95%

Formula Markup: C24H40O3

Formula Weight: 376,6

Shelf life (days): 1460

CAS Number: 2276-93-9

Notes: Alloisolithocholic acid is a metabolite of the secondary bile acid metabolite 3-oxo lithocholic acid (dehydrolithocholic acid; Item No. 29544).{62987} It is formed from 3-oxo lithocholic acid by gut microbiota.{62987} Alloisolithocholic acid (20 µM) increases the association of the nuclear hormone receptor nerve growth factor IB (Nr4a1) to the gene encoding forkhead box protein P3 (Foxp3) in isolated mouse CD4+ T cells. It induces the differentiation of isolated mouse T cells into regulatory T cells (Tregs) and the production of mitochondrial reactive oxygen species (ROS) in isolated mouse CD4+ T cells when used at a concentration of 20 µM.{53583} Alloisolithocholic acid (6 mg/kg) reduces hepatic bile flow and bile salt, cholesterol, and phospholipid secretion, as well as induces loss of microvilli and dilation of canaliculi in hepatocytes, markers of cholestasis, in rats.{53939} Fecal levels of alloisolithocholic acid are reduced in patients with Crohn’s disease or ulcerative colitis.{62987}

• Artikelnummer: CAY29542-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29542-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK