Almorexant-13C-d3, CAS 2738376-75-3

Formulation: A solid

Formal Name: (R)-2-((S)-6,7-dimethoxy-1-(4-(trifluoromethyl)phenethyl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-(methyl-13C-d3)-2-phenylacetamide

Purity: ≥98% deuterated forms (d1-d3)

Formula Markup: C28[13C]H28D3F3N2O3

Formula Weight: 516,6

Shelf life (days): 1460

CAS Number: 2738376-75-3

Notes: Almorexant-13C-d3 is intended for use as an internal standard for the quantification of almorexant (Item No. 13638) by GC- or LC-MS. Almorexant is a dual antagonist of orexin 1 receptor (OX1R) and OX2R (Kis = 4.7 and 0.9 nM, respectively, in a radioligand binding assay).{28150} It decreases the latency to persistent non-rapid eye movement (NREM) sleep and increases the duration of NREM and REM sleep in male rats when administered at a dose of 100 mg/kg.{49493} Almorexant (300 mg/kg) does not impair spatial learning and memory in the Morris water maze and does not reverse spatial memory impairments induced by scopolamine in rats.{49494}

• Artikelnummer: CAY29099-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29099-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung