Almotriptan (malate), CAS 181183-52-8

Formulation: A crystalline solid

Formal Name: 2-hydroxy-butanedioic acid, compd. with N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine

Purity: ≥98%

Formula Markup: C17H25N3O2S • C4H6O5

Formula Weight: 469,6

Shelf life (days): 1460

CAS Number: 181183-52-8

Notes: Almotriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 12 and 13 nM, respectively, in a radioligand binding assay).{47183} It is selective for human 5-HT1B and 5-HT1D receptors over rat 5-HT1A and human 5-HT2A and 5-HT4 receptors (IC50s = 0.85, 25.1, and 140 μM, respectively). Almotriptan induces contractions in isolated canine saphenous veins (EC50 = 394 nM) but not isolated rabbit renal or mesenteric arteries. It increases carotid vascular resistance in anesthetized cats (ED100 = 11 μg/kg, i.v.) without increasing blood pressure or heart rate.{47184} Formulations containing almotriptan have been used in the treatment of migraine headaches.

• Artikelnummer: CAY25646-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25646-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK