Alprenolol, CAS 13655-52-2

Formulation: A crystalline solid

Formal Name: 1-[(1-methylethyl)amino]-3-[2-(2-propen-1-yl)phenoxy]-2-propanol

Purity: ≥98%

Formula Markup: C15H23NO2

Formula Weight: 249,4

Shelf life (days): 1460

CAS Number: 13655-52-2

Notes: Alprenolol is a non-selective β-adrenergic receptor (β-AR) antagonist that is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT1B.{25151,41186} It binds to β1-, β2-, and β3-ARs expressed in CHO cells (Kds = 15, 0.91, and 117 nM, respectively, for the human receptors) and to 5-HT1A and 5-HT1B receptors in rat hippocampal and striatal membranes (Kis = 34 and 134 nM, respectively).{25151,41186} In vivo, alprenolol (40 mg/kg, i.v.) completely blocks the hyperactivity response of rats to 2-PCPA (Item No. 10010494) and L-tryptophan.{25891} Alprenolol (10 μg, i.v.) inhibits decreases in heart rate and left ventricular systolic pressure induced by the β2-AR antagonist ICI 118551 (Item No. 15591) in transgenic mice overexpressing the β2-AR.{36710} It also reduces the level of abnormal prion fibrils (PrPSc) in the brain of mice intracerebrally infected with prion disease to less than 20% of control levels when administered in drinking water at a dose of 50 mg/L.{36711}

• Artikelnummer: CAY25338-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25338-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK