Altenusin, CAS 31186-12-6

Formulation: A solid

Formal Name: 3,4',5'-trihydroxy-5-methoxy-2'-methyl-[1,1'-biphenyl]-2-carboxylic acid

Purity: ≥98%

Formula Markup: C15H14O6

Formula Weight: 290,3

Shelf life (days): 1460

CAS Number: 31186-12-6

Notes: Altenusin is a polyphenol fungal metabolite originally isolated from the fungus Alternaria that has diverse biological activities.{47219,47220} It inhibits Src kinase with an IC50 value of 20 nM.{47221} Altenusin inhibits fibrillization of recombinant tau fragments in vitro and phosphorylation of tau in SH-SY5Y cells expressing human P301L mutant tau when used at a concentration of 10 μM.{47219} It is an agonist of the farnesoid X receptor (FXR; EC50 = 3.2 μM) that reduces blood glucose, serum insulin, and serum cholesterol levels, as well as hepatic lipogenic gene expression and steatosis, in a high fat diet-induced mouse model of obesity when administered at 30 mg/kg per day.{47220} Altenusin also has antioxidant and antifungal properties.

• Artikelnummer: CAY26911-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 26911-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK