Alvimopan, CAS 156053-89-3

Formulation: A crystalline solid

Formal Name: N-[(2S)-2-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]-glycine

Purity: ≥98%

Formula Markup: C25H32N2O4

Formula Weight: 424,5

Shelf life (days): 1460

CAS Number: 156053-89-3

Notes: Alvimopan is a μ-opioid receptor antagonist (Ki = 0.47 nM).{25494} It is selective over the κ- and δ-opioid receptors (Kis= 100 nM and 12 nM, respectively). Alvimopan inhibits μ-opioid receptor-mediated GTP binding to CHO cell membranes with an IC50 value of 1.7 nM. It inhibits morphine-induced slowing of colorectal transit in mice with an ED50 value of 0.41 mg/kg.{39510} Alvimopan (0.3 and 1 mg/kg, p.o.) reduces inhibition of gastrointestinal (GI) transit induced by morphine, but not apraclonidine (Item No. 23904), in rats. Formulations containing alvimopan have been used in the treatment of opioid-induced bowel dysfunction.

• Artikelnummer: CAY23902-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23902-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK