AM80, CAS 94497-51-5

Formulation: A crystalline solid

Formal Name: 4-[[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]-benzoic acid

Purity: ≥98%

Formula Markup: C22H25NO3

Formula Weight: 351,4

Shelf life (days): 1460

CAS Number: 94497-51-5

Notes: AM80 is a retinoic acid receptor agonist that is selective for RARα (Kd = 62 nM; AC50 = 1.46 nM) compared to RARβ (Kd = 280 nM; AC50 = 6.87 nM) and RARγ (Kd = 816 nM; AC50 = 148.7 nM).{24736} It demonstrates greater specific binding to RARα compared to retinoic acid (Item No. 11017), which exhibits little selectivity across RARα, β, or γ.{25644,24736} AM80 exhibits antiproliferative effects against acute promyelocytic leukemia cells, inducing human promyelocytic leukemia HL-60 cell differentiation with an ED50 value of 0.79 nM.{23266,25644} It has also been shown to suppress the growth of other myeloid and lymphoid malignant cells.{25644}

• Artikelnummer: CAY71770-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 71770-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK