Ambrisentan, CAS 177036-94-1

Formulation: A crystalline solid

Formal Name: αS-[(4,6-dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-phenyl-benzenepropanoic acid

Purity: ≥98%

Formula Markup: C22H22N2O4

Formula Weight: 378,4

Shelf life (days): 1460

CAS Number: 177036-94-1

Notes: Ambrisentan is a nonpeptide endothelin A (ETA) receptor antagonist (IC50s = 0.251, 0.316, 0.398, 251, and 630 nM for rat preparations of heart, bladder, kidney, lung, and cerebral cortex, respectively).{37346} It inhibits contraction of isolated rabbit aortic rings induced by endothelin-1 (ET-1; Item No. 24127) by 43.23% when used at a concentration of 1 µM.{37347} Ambrisentan inhibits ET-1-induced contraction of human pulmonary and radial arteries in vitro (Kd = 0.042 and 0.11 μM, respectively).{37348} In a rat model of neonatal hyperoxic lung injury, ambrisentan (20 mg/kg per day, s.c.) reduces pulmonary arterial hypertension (PAH) as well as decreases PAH-induced right ventricular hypertrophy (RVH) and peak RV pressure.{37349} Formulations containing ambrisentan have been used in the treatment of PAH.

• Artikelnummer: CAY23669-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23669-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK