Ambrisentan-d3, CAS 1189479-60-4

Formulation: A crystalline solid

Formal Name: 2-((4,6-dimethylpyrimidin-2-yl)oxy)-3-(methoxy-d3)-3,3-diphenylpropanoic acid

Purity: ≥99% deuterated forms (d1-d3)

Formula Markup: C22H19D3N2O4

Formula Weight: 381,4

Shelf life (days): 1460

CAS Number: 1189479-60-4

Notes: Ambrisentan-d3 is intended for use as an internal standard for the quantification of ambrisentan (Item No. 23669) by GC- or LC-MS. Ambrisentan is a nonpeptide endothelin A (ETA) receptor antagonist (IC50s = 0.251, 0.316, 0.398, 251, and 630 nM for rat preparations of heart, bladder, kidney, lung, and cerebral cortex, respectively).{37346} It inhibits contraction of isolated rabbit aortic rings induced by endothelin-1 (ET-1; Item No. 24127) by 43.23% when used at a concentration of 1 µM.{37347} Ambrisentan inhibits ET-1-induced contraction of human pulmonary and radial arteries in vitro (Kd = 0.042 and 0.11 μM, respectively).{37348} In a rat model of neonatal hyperoxic lung injury, ambrisentan (20 mg/kg per day, s.c.) reduces pulmonary arterial hypertension (PAH) as well as decreases PAH-induced right ventricular hypertrophy (RVH) and peak RV pressure.{37349} Formulations containing ambrisentan have been used in the treatment of PAH.

• Artikelnummer: CAY35558-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35558-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung